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#114450 - 06/05/15 06:39 AM Re: polydactyly and polyphalangy [Re: Wieslaw]
Robbie Offline
Flock Leader

Registered: 01/19/15
Posts: 258
Loc: Ontario Canada
There is a brief description of the Bejing You mentioned in that publication in Sigrid Van Dort's book, Genetics of the Chicken Extremes. It's a very late maturing broiler breed, with leg feathers, beard, tassel (?), single comb, and some have five toes.

#116648 - 06/05/17 08:50 AM Re: polydactyly and polyphalangy [Re: Robbie]
Robbie Offline
Flock Leader

Registered: 01/19/15
Posts: 258
Loc: Ontario Canada
Here's a new paper on polydactyly in the Bejing Fatty.

Genetic pattern and gene localization of polydactyly in Beijing fatty chicken

Chuan He,
Yongcan Chen,
Kaixuan Yang,
Zhengxiao Zhai,
Wenjing Zhao,
Shuyun Liu,
Jinmei Ding,
Ronghua Dai,
Lingyu Yang,
Ke Xu,
Zhenxiang Zhou,
Caiju Gu,
Qizhong Huang ,
He Meng


Published: May 10, 2017

Abstract: Polydactyly, a common heritable limb malformation in vertebrates, is characterized by supernumerary digits. In chickens, basic characteristics and rough dominant genes have been explored in past decades; however, the elaborate pattern of inheritance and the determinant gene remain obscure. In this study, different types of polydactylism were classified by the numbers and the shapes of toes, including the newly defined subtypes of B and G, for the Beijing fatty chicken, a native breed of chicken from China. Through experiments on hybridization, we demonstrated a complete dominant inheritance of polydactyly instead of an incomplete penetrance or genetic modification of the previous conjecture. In particular, by using the F2 population of the five-digit purebred line of Beijing fatty chicken backcrossed to Shiqiza chicken and by using restriction-site associated DNA based markers, we performed a genome-wide association study on the trait of polydactyly. Furthermore, whole genome resequencing strategy was applied to sweep SNPs across the whole genome. An outlier-based Fst approach was employed to search for signatures of selection, and results indicated that the determinant mutation was found in the region ranging from 8.3 Mb to 8.7 Mb, where the polydactyly candidate gene LMBR1 was located. The G/T mutation of rs80659072 was identified to be highly associated with polydactyly in our resequencing and was validated in random samples from an expanded population. Thus, we confirmed that LMBR1 was the causative gene of polydactyly in the Beijing fatty chicken by using GWAS with restriction-site associated DNA based markers and resequencing.

#116655 - 06/06/17 09:46 PM Re: polydactyly and polyphalangy [Re: Robbie]
KazJaps Offline
Classroom Professor

Registered: 08/30/02
Posts: 2864
Loc: Australia
Thank you Robbie. I'll put a link in the journal papers ref. thread too.

That has the Po Chinese (& Sultan?) mutation covered. Unfortunately I don't think they DNA tested the Po European allele (Houdan, Faverolle, Dorking)?

eg, previous 2016 Po study:

Zhang, Z., Nie, C., Jia, Y., Jiang, R., Xia, H., Lv, X., Qu, L. (2016).
Parallel Evolution of Polydactyly Traits in Chinese and European Chickens.
PLoS ONE, 11(2), e0149010.

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